When we observe an Orange in its
separate structures, we find the rind pungent, the pulp acid and the seeds
bitter. When we move from the exterior towards the interior, judging from the
taste and to some extent the colour, the forces seem to transform from a centrifugal
direction towards a contracting and finally descending and gathering motion.
It’s noteworthy that both peel and
seeds of orange store oils, are in fact mostly the same essential oil, namely D-Limonene,
(peel 90.58%, vs seed 81.73%), yet both contain an important proportion and
concentration of the remaining nineteen different essential oils present in
oranges. Both the external visible skin and the deep-seated seeds are
interconnected by their oils. So, the question is, what are the nature of the relationships
between the skin and seed of the orange?
Similarly, in the human body we find
correspondences between the skin and innermost organs. Chinese medicine links surface Tai Yang with
deep rooted Shao Yin. The Nei Jing is also an in-depth analysis of
the relationship of the cosmos to human health. Our question is what is the
nature of the outer influences on the inner organs.
The premise we will work from is
that Physics dictates biology and not vice versa. Sun and skin biology
determine the function and wellbeing of the inner organs. In the realm of biology however, Quantum
physics holds a special place, and its influence is conveyed by a triangle of
Light, Water and Magnetism. In this respect, we may say that Light is predominant in Heaven, and
Magnetism on Earth, and Water in Man. We can also add that, the Great Yang,
(Tai Yang 太阳) as the sun
is called in mandarin is a positive cathode, and the Earth (Di 地) is a negative
anode, and to complete the circuit we have the water content in Man.
We have found, both theoretically
and in clinical practice, the practice of taking sunlight while standing
barefoot, and under the conditions of proper hydration, are deeply therapeutic.
This we call the “The Tree Cure”, it simply takes the basic elements required for
life as a tree, namely water, sun and earth. It is a practical application of the
philosophy Heaven, Earth, Man. Practiced
daily, there seems to be no medical condition which cannot benefit, improve or
completely resolve from the “Tree Cure”.
Its no simpler than drinking water, removing shoes and shirt, and to sit or stand
barefoot on the grass or soil.
Within Chinese cosmogenesis, we have
two different modalities, the Created Axis, where Man stands Between Heaven and
Earth, and a Creative Axis, where Heaven creates Earth, and Earth Creates Man. The
creative axis, which is considered prenatal, seems to be in harmony with the understanding
that Light is also a form of electromagnetic force, and it is the influence of
these two subtle forces which finally shape an determine the ultimate course of
human biochemistry.
What is visible (看得见), is yin, what is not visible (看不见) is Yang. Light force and EMF belong to Yang.
Tian, 天 Heaven Light
Ren 人 Man Water
Di 地, Earth Electromagnetic field
When a cell wants to divide,
previous to its passage of the various the phases of cell mitosis (interphase,
prophase, metaphase, anaphase and telophase), there is an important phenomenon
that takes place. With the help of a photo multiplier, we are able to observe
that in every instance there is an emission of light, in the form of bio-photon,
or extreme low frequency UV light (Van Wick 2016). It is a spark of light that
gives the signal for the cell to enter cell DNA replication and cell
division. A strong cell anchors light,
in the same way a good blood stores the warmth of yang. In his book “Light in
Shaping life”, Roeland Van Wick explains that weak and deficient tissues like
tumours emit light, healthy tissues do not drop its energy quanta with light release.
We can say that the voltage of a
cell, its zeta potential, and its redox potential are enhanced by regular sun
exposure. It is in fact the action of the sun over water. Tai yang and Shao yin
rule water. Injury to Tai Yang 太阳conformation develops into cold damage, all the first chapter of the
Shan Han Lun is devoted to this subject. But perhaps we fail to acknowledge the
role of Tai yang in health, which is to warm the water and blood: UV and IR
both stimulate these cell energy expressions. If the cell does not receive
energy from magnetic fields, and light, it will have a hard time to generate
the necessary bio-photons for cell division.
In that case, as an adaptation mechanism, the cell activates a unique
response.
About 5 to 8 percent of our genome
is retrovirus. The Human Endogenous Retrovirus (HER) is a retrovirus which is
part of the human genome. It’s a virus that
can behave as an oncogene, yet it has a vital function in human life. The
placenta displays a vast activity of HER; in fact most mammals have this virus
active in gestation. it is believed to have a role in securing the immune
system is compatible with the genetic information carried in the foetus. In
adult life these retroviruses perform many vital functions when editing the
genome is called for.
It’s our hypothesis that lack of
normal healthy bio-photon emission, challenges healthy
cell division, and guides de cell along adaptive biochemical pathways. It
possible that HER is activated to edit the genome, enabling it to allow cell
division. The use of retrovirus as an adaptive mechanism that has enabled a
faster evolution.
It appears that even though HER activity is a mechanism
that supercharges the adaptability of the human species, HER activity over an extended
period of time can alter the genome information, to an extent that it becomes
unfavourable, especially if causative factors have not been addressed. For example,
promoting uncontrolled cell division. It is known that HER is a retrovirus
commonly active in many forms of cancer, and autoimmune diseases. (Matteucci 2018)
HER is particularly active in
cancers, and autoimmune diseases often associated with low vitamin D levels,
like colorectal and gastric cancer, also hormone dependant breast and prostate
cancer, likewise autoimmune diseases like multiple sclerosis, LUPUS and ALS,
which are also associated with low vitamin D levels. This leads to the insight
that deep seated genetic disorders (Shao yin), may find resolution and healing,
when the surface skin biology (Tai Yang) is heeded. IT also explains why both
Tai Yang and Shao yin are related, and why both belong to the exterior.
One may prescribe many appropriate
Fu Zi medications, for Internal Shao yin, yet if the physics of the environment
are ignored, the results will be unsatisfactory.
When we observe a group of firemen around a fire, we don’t think of them
as guilty of the incident. However, when we find cholesterol plaques in the
scene of a heart attack, or a stroke, we find it responsible for a crime
against life. We seem to hold a rather reductionist view about cholesterol; Cholesterol= fat=
atherosclerosis=compromised cardiovascular system= blood clot= stroke= death. Cholesterol has become a sensitive theme of
nutrition, a terror for many, but how rational and legitimate is this anxiety?
The biochemistry of the body can be
divided by two big fractions; those which dissolve in fat, (lipophilic) and
those which dissolve in water (hydrophilic). Cholesterol belongs to the first
group, but it has a unique versatile quality, both hydrophilic and lipophilic
when it converts to cholesterol sulphate. As if a ghost it can move freely,
within spaces, where cholesterol normally has no access. (Rodríguez 1995).
Before the abundant arrival of
oxygen, the first forms of life evolved in the form sulphur metabolizing
bacteria. Sulphur and oxygen are two key molecules for life. Sulphur has a
heterogenous range of valences, from -2 to +6. Yet for health we are especially
interested when its bonded to oxygen, sulphate, SO4, were we have 4
critical molecules of oxygen, also it expresses a valuable negative charge (SO4-2).
The negative charge of cholesterol sulphate gives voltage, electric charge
promotes circulation, and repels agglutination.
Like oxygen, sulphur supports
aerobic metabolism. From the intuitive sphere of beliefs of alchemists there
are three elements related to fire; phosphorus, sulphur and oxygen. In the
blood this subtle radiance is called "Zeta potential", a scientific expression
coined to describe the electrical charge or electro-kinetic potential in fluids,
usually expressed in millivolts. The magnitude of zeta potential indicates the
degree of electro static repulsion between the particles in a solution. A high
Zeta potential indicates resistance towards coagulation, low levels of zeta
potential indicates that the colloid tends to aggregate or decant.
In a review of 12 clinical trials, a meta-analysis involving more than 5000 patients, there was no reduction in
myocardial infarction attributable to the use of angioplasty in any of their
presentations.
"Conclusions;
In patients with chronic and stable coronary disease, in the absence of a
recent myocardial infarction, percutaneous coronary intervention offers no
benefit in terms of death, myocardial infarction, or the need for subsequent
revascularization compared with conservative medical treatment. "
(Katritsis 2005)
The way the body sulphates cholesterol is through the action of
ultraviolet light. In the same way, that vitamin D becomes sulphated vitamin D under
UV. Another great sulpho-lipid hormone, key to hormonal health in men and
women, which also derives from cholesterol, is DHEA, (dehydroepiandrosterone).
We could say that cholesterol is a very special molecule, but acquires extraordinary
properties when it is activated by the sun.
Sulphated cholesterol is a critical protector of the heart and
cardiovascular system (Ma 2008). It delivers oxygen to the muscles through
myoglobin, provides cholesterol to the cell membrane, provides energy to the
cell.
A cell membrane made of cholesterol has different and lower properties
than a membrane formed by sulphated cholesterol. It is in our benefit that cell
membranes are built from sulphated cholesterol. The speed of exchange along the
membrane of cholesterol sulphate is an order of magnitude faster than un-sulphated
cholesterol (Rodríguez 1995). Even so, it would be pertinent to add that the type
fat which damage the permeability of the membranes, and increase the risk of
primary cardiac arrest, are trans fats (Lamaitre 2005).
Thrombin is an enzyme that plays an important role in blood
coagulation, it has been noticed that cholesterol sulphate serves as an
inhibitor of thrombin in blood plasma (Iwamori 1999).
The solar radiation over the skin, fulfils the role of converting
nitrates, (NO3), into nitrites, (NO2), and finally nitric
oxide, (ON), (Weller 2010). This gas, is produced in the epithelium of the
arteries it then diffuses into the smooth muscle of the arterial intima and
generates arterial vasodilation.
NO-3àNO-2à ON
In a quest for pectoral angina
remedy by serendipity scientist discovered Viagra
where its active ingredient is sildenafil which supports production of nitric
oxide (NO). The NO dilates and promotes circulation, the sun therefore acts as
an antihypertensive agent. It has been observed that an effective and unfailing
medicine for high blood pressure is exposure to sunshine. (Vatakencheryy
2019, Kiani 2018) Remove the shirt and shoes and receive 20 minutes of
sunshine, severe hypertension may need two similar sessions a day.
Some
researchers (Nathan 2010), believe we have wrongly blamed cholesterol as focal
target responsible for cardiovascular health, when the problem is a decline in
nitric oxide production with age.
The
biological motive for stimulating vascular dilatation, is to increase the surface
exposure of the blood to facilitate greater contact of cholesterol and red
blood cells to ultraviolet radiation.
Red blood
cells have two proteins, haemoglobin which absorb infrared light, while
porphyrin absorbs ultraviolet light. Here again we have a photoelectric effect acting
on red blood cells, to give them propulsion, a movement with anti-agglutinating
repellent forces.
Photons
acting on the surface of the skin generate a phenomenon called Rayleigh-Bénard
convection. To understand this force, let's use the analogy of porridge
bubbling in the pot. The heat emitted on a single surface generates a circular
movement of the fluids, from the inside out. Thus the deep seated blood,
emerges, circulates and takes contact with the sun.
On the other hand, water being a
polar substance, exposed to photons can be divided, in proton, H +, and hydroxy
radical OH-, the sun will separate the charges of water that will take contact
with hydrophilic substances such as collagen. We will then have a power source
and DC voltage. These electrons and protons will be available for the
mitochondria, both the electron transport chain and the proton gradient. The
interaction of sun and water creates energy.
When the body raises LDL cholesterol,
it actually does so for two possible reasons; first it is an indication of low
levels of cholesterol sulphate. Cholesterol sulphate inhibits the synthesis of
cholesterol (Strott 2003). Another common event is the role of cholesterol in
neutralizing endotoxins and bacteria. Few understand that cholesterol plays an
antibiotic and cleansing role, it absorbs and purifies the body of intestinal
endo-toxins, particularly Lipopolysaccharides (LPS) of Gram-negative bacteria
(Kitchens 2003) (Kazuyuki). As a summary, we can say
that when the body raises cholesterol, we should try to understand the
mechanisms it seeks to compensate.
The sun energises to the blood, we
can see in the zeta potential. Cholesterol sulphate gets finally converted into
calcitriol the active form of vitamin D in the Kidney. Cholesterol sulphate is
also a key nutrient for heart cardiocytes. Heart and Kidney link via Shao yin
becomes evident as does the interdependence with surface Tai Yang.
If excess carbohydrates are
consumed, the microbiome will become simplified, leading its way to intestinal
dysbiosis and overgrowth of beta-proteo-bacteria, a group of highly inflammatory
Gram-negative bacteria predominate. The intestinal inflammation, causes
increased intestinal permeability. By the phenomenon called translocation of
endo-toxins, lipopolysaccharides LPS leak to the plasma, the blood becomes
toxic, and the body uses cholesterol as a sponge to absorb and neutralize the
LPS (Kitchens 2003). When the body raises cholesterol it’s because it deeply
knows what it’s doing, using a statin does not solve the inflammatory problem,
or blood viscosity, intestinal permeability, or lack of sulphated cholesterol,
actually reduces cholesterol sulphate. (Senneff 2011).
In the colon once again, we find something
interesting, to heal and regenerate an intestine, activation of intestinal stem
cell is needed, who activates this cell is vitamin D. Hence, colon cancer is strongly
linked with vitamin D deficiency. Vitamin D down regulates the expression of
Beta catenin, a protein that when over
expressed, causes activation of colorectal cancer stem cell
processes (Yilmaz
2018). The intestinal tight junctions create the barrier that controls
intestinal permeability. However, it degrades and ruptures when vitamin D
levels fall below 30 ng / ml. On the other hand, subcutaneous fat, is the most
important reserve of stem cells, is the reserve bank for all forms of
regeneration that the body will need during life. One way to activate the stem
cells of subcutaneous fat is by means of infrared light over the abdomen
(Emelyanov 2015).
Whether it be intestinal stem cell
lying in the crypt of the intestinal villi, or dormant stem cells in
subcutaneous fat, in both cases their activation is dependent on a surface
event initiated by exposure to sunlight, UV and IR respectively. Ancestral Jing
essence 精 is activated by
the suns electromagnetic forces.
The reason why it is not a good idea
to ingest vitamin D capsules, is because it carries the message to the body
that has sulphated cholesterol, and halts a cascade of key biochemical pathways
for cardio- vascular health. Also, as we have explained the sun offers a host
of other benefits, which are not vitamin D related. The prevailing thought,
practiced by millions, is reasoning, the sun is dangerous, and it will be
better to ingest vitamin D in capsules. Vitamin D carry no yang EM forces, and
will not interact with skin chemistry, thus failing to create the
external/internal dynamics explained in Chinese medicine.
Skin cancer and ultra violet: Within the skin there is a sinister path, its
starts in actinic keratosis, a precancerous lesion, and advances towards
cutaneous squamous cell carcinoma, in an order of evolution ranging from 0.025%
to 16%, (Ratushny 2012). If this is not controlled, we have invasive cutaneous
carcinoma.
The mechanism by which ultraviolet
rays can activate the path towards cancer is through the effect of UVB on a
tumour suppressor gene, p53 (Ratushny 2012). But perhaps it is a simplistic and
incomplete position to declare that ultraviolet is carcinogenic. With this
argument it would also be valid to incriminate oxygen as highly toxic, omitting
mention that it is also essential for life.
The agent that inactivates the p53
gene, namely UVB, is the same one that generates vitamin D, which several meta-analyses
reveal is protective against cancer. (Grant 2017) (Cedric 2006) (Autier 2007).
The consensus of these studies indicates that an effective prophylaxis to avoid
cancer is to maintain high levels of vitamin D, plasma levels between 70 and
100 ng / ml. Ignorance added to fear always brings problems, in this case, fearing
skin cancer, the public could be exposed to a higher risk of contracting other
types of neoplasm. Additionally, the antitumor and cancer-preventive action of
sun exposure is not limited to vitamin D (Hanvan 2012)
It is only excessive exposure to UVB – excessive to the point
of photo-carcinogenesis – that de-activates the cancer suppressor gene
p53. Naturally, common sense and moderation must prevail.
Vitamin D is protective against
cancer. However, many of the anti-tumour effects attributed to vitamin D may
also be benefits of cholesterol sulphate. It protects against cancer, diabetes
and improves immunity. (Mitri 2013) (Papandreu 2015)
Epidemiology and geography studies
indicate that the sun is protective of cardiovascular diseases (Weller 2010).
If there is a lack of exposure to the sun, through the same metabolic pathway of
cholesterol synthesis, the body generates cholesterol instead of generating
vitamin D. This is confirmed by the fact that the body raises cholesterol in
winter (Grimes 1996).
Observing the axis on the table
referring to death rate, we ask ourselves why institutions do not promote the
sun, while conversely sunscreen is promoted. It is worth remembering that the
different types of skin cancer do not appear even among the first 10 causes of
death. In the statistics of deaths from cancer itself, lung cancer occupies the
first place, while melanoma and squamous cell skin cancer occupy 23 and 24
respectively, in spite of the fast-growing number of cases.
Very low levels of cholesterol are now
frequently found in humans, and are more dangerous than high levels. Perhaps
the central question is not how to reduce cholesterol levels, the story is more
complex, more accurate is to ask what mechanism is failing and thereby causing
the body to raise cholesterol as a measure to ensure balance and homeostasis?
Cholesterol sulphate is produced by the action
of solar radiation on cholesterol at the skin surface. It serves as a substrate for the
synthesis of sulphated steroids, such as DHEA sulphate, and pregnenolone sulphate
(Gurpide 1966). From pregnenolone we obtain the hormones like oestrogen,
progesterone and testosterone. Cholesterol sulphate is present in high concentrations
in the male reproductive tract, avidly absorbed in the outer membrane of the
sperm. Within the epididymis of the testis cholesterol sulphate stabilizes the
sperm and inhibits the acrosin protease, which activates the metabolic pathway
of fertilization. Within the female reproductive tract, the sulphate radical is
released, inhibition is reversed, and there is a cascade of events called
acrosome reaction that leads to fertilization (Langlais 1981). In all these
events we observe immersion of surface yang, working its way towards yin. Like the oils from the skin towards the seed
of an orange.
The journey towards sleep starts
with tryptophan an aromatic amino acid, which is highly sensitive to UV light,
this amino acid is the building block for serotonin. Melatonin it created in
the eye with the help of ocular melanocytes, converting serotonin to melatonin
with the help of UV light, then stored in pineal gland. Interesting to observe
that something which is created with light gets only gets released in darkness.
The discourse up to this point, draws on cited
studies to develop our understanding of
the exterior-interior, Yang-Yin relationships of processes
and chemical pathways which, in the absence of (sufficient)
exposure to solar radiation, give rise to pathology.
If one considers that the skin as a
supplier of cholesterol sulphate, and nitric oxide, then the skin could be
understood as a large solar panel which provides energy to the heart. It also
provides electrical charge for porphyrin and haemoglobin, as well as managing
the separation of charges from water. The sun transforms solar energy to
chemical energy, especially in the links between cholesterol and sulphate, as
well as vitamin D and its sulphate.
Nitric Oxide is an important
metabolic modulator of the mitochondria, and it is worth remembering that the
mitochondria, which represent 30% of the weight of the heart, also has four
proteins that are chromophores of light, the first respiratory complex absorbs
ultraviolet, the cytochrome c oxidase of the third respiratory complex absorbs
infrared, and the Hem proteins of the ATP synthase of the fifth respiratory
complex absorb both UV and IR. Both animal mitochondria and plant chloroplast derive
evolutionarily from a symbiosis of bacteria, from the family of cyanobacteria
and rickettsia respectively. While the chloroplast synthesizes carbohydrates
the mitochondria burns carbohydrates, the first emits oxygen and the second
consumes it, the chloroplast absorbs CO2, while the mitochondrion releases it,
but the common characteristic of both is to originate from a symbiotic relation
with bacteria and to be light
chromophores.
There are various elements of physics that determine
biochemistry which deserve to be researched. Chinese medicine is based on a central
premise. 气 为 血 之 帅, 血 为 气 之 母. "Energy is the commander of blood, blood
is the mother of energy". A purely biochemical and molecular paradigm is insufficient.
Diet or medication is not necessarily the only or best way to heal. The “exposome”
variable, that is, the sum of environmental influences, also deserves
consideration.
The forces of the sun
act primarily from the exterior towards the interior, via the eye and the skin.
The heart takes oxygen from the exterior towards the inner cell. Yang is a
centripetal motion, whereas yin is centrifugal in its direction. We can observe that every cell has 2 major
centres, the metabolic centre is the mitochondria (which has several chromophores)
and the genetic centre is within the nuclear membrane.
The moon governs
reproduction and monthly cycles, while sun governs daily circadian rhythms. Sun
governs the cortisol/melatonin axis, cortisol is liberated in the morning,
around 5 am, while melatonin is freed around 9 pm. Melatonin is the hormone of
light, its created with light, it’s an action of UV light over tryptophan, and
subsequent conversion of serotonin, yet it will only be released in
darkness. If circadian rhythm is altered
there can be no harmony at the endocrine level.
The reproductive
hormones, are also influenced from cholesterol sulphate, and its generator the
sun photons. But the movements of
progesterone and oestrogen follow a monthly rhythm.
We return to the relationship between
Heart and Kidneys. They are bound in a Shao yin relationship, as a continuous
meridian, shao yin of hand and shao yin of foot. Yet also this couple of inner
organs is once again paired with Tai Yang on the exterior.
Tai Yang normally uses pungent Gui Zhi (RAmulus cinamoni) and Ma
Huang (Ephedra sinica) to open
the surface, while Shao Yin Uses Fu Zi (Aconitum carmichaelii) a gathering and astringent
pungent, to open the paths. The point we
want to make is that though they are both pungent, the direction of the force
is opposite. The other noteworthy point is that Gui Zhi is the exterior (bark)
and Fu Zi is the interior (root).
IF the shao yin governs Jing and
hereditary energy, Tai Yang governs epigenetic expression of genes. Epigenetic
phenotype is able to override the genetic blueprint. It is the suns who work on
surface biochemistry that modulates genetic expression. IT is therefore the sun (yang) through its
action on the skin, whom to a large extent determines the inner workings of the
interior, including hormones, genes and blood. Adequate sun exposure is able to
override gene expression. One important mechanism is via the retrograde
signalling from Mitochondria towards nuclear DNA (Bagkos 2015). What needs to
be made clear is that the processes that take place in human physiology are not
merely biochemical phenomena, Electromagnetic forces
govern biochemistry.
According to the Shang Han Lun, we have 3
levels of paired interaction. Exterior, half interior half exterior and
Interior.
Tai Yang – Shao Yin = Exterior
Jue yin – Shao yang=
Half Interior half exterior
Yang Ming- Tai
Yin= Interior
Another
perspective and insight originates from understanding embryology. The ectoderm
is where cells of skin and nervous system are derived. In fact, epidermis skin
cells, neurons of the brain and pigment cells, all derive from the Ectoderm.
The narrative of the Nei Jing is based on space
and time dynamics. The oxygen, zeta potential, and sulphates in blood all come
from the environment. Light,
water and magnetism are the primary forces of biology. Biology does not
determine the laws of physics; it is physics who regulates and defines biology
at all levels. On the other hand, unlike Chinese classic texts, in modern academic
circles, the progress of the science of physics shows a low level of
interaction with the development of biology.
It is evident that modern life, has
led humanity towards artificial electromagnetic fields, artificial light and
indoors living, and bad quality water. We assert that the “Tree cure”, regardless of how simple it may seem, is a fundamental
medicine to restrain or resolve medical conditions, both hereditary and
epigenetic. The Tree cure is based on the medicines of a tree, namely sun,
earth and water, stand barefoot on earth with no shirt and drink water.
Placing the cosmic sun as a central axis in the
pathologies of the heart, is a bold and novel concept, of which requires
equally extraordinary level of evidence. We assert that the scientific
exploration of these relationships between solar radiation and the biochemistry
of blood will be a rich source of inquiry and lead to positive outcomes for the
prevention and management of cardiovascular and other chronic diseases. Equally
important is understanding of the diverse mechanisms by which solar energy via
the skin is able to heal the deeper layers of the body, affecting blood,
cholesterol, endocrine system and the genome.
References:
1. Autier,Philipe
MD; Sara Gandini, PhD. Vitamin D Supplementation and Total
Mortality A Meta-analysis of Randomized Controlled
Trials. 2007.
2.
Axelson. Magnus, "25-Hydroxyvitamin D3 3-sulphate
is a major circulating form of vitamin D in man," FEBS Letters
(1985), Volume 191, Issue 2, 28 October, Pages 171-175;
doi:10.1016/0014-5793(85)80002-8
3.
Bagkos, Georgios Kostas
Koufopoulos, Christina Piperi. Mitochondrial
emitted electromagnetic signals mediate retrograde signaling. Department of Biological Chemistry,
University of Athens Medical School, Athens, Greece. 2015
4. Cedric F.
Garland, DrPH, Frank
C. Garland, PhD, Edward
D. Gorham, PhD, MPH, Martin
Lipkin, MD,Harold
Newmark, ScD, Sharif
B. Mohr, MPH, and Michael
F. Holick, MD, PhD The Role of Vitamin D in Cancer
Prevention. 2006.
5.
DiMarco DM1, Missimer A1, Murillo AG1, Lemos BS1, Malysheva
OV2, Caudill MA2, Blesso CN1, Fernandez
ML3. Intake of up to 3 Eggs/Day Increases HDL Cholesterol
and Plasma Choline While Plasma Trimethylamine-N-oxide is Unchanged in a
Healthy Population. Lipids. 2017 Mar;52(3):255-263. Epub
2017 Jan 13.
7.
Emelyanov AN1, Kiryanova VV. Photomodulation of proliferation and
differentiation of stem cells by the visible and infrared light. 2015.
8.
Godley, Bernard F,
Farrukh A. Shamsi§**, Fong-Qi Liang‡, Stuart G. Jarrett, Sallyanne Davies, and
Mike Boulton. Blue Light Induces Mitochondrial DNA Damage and Free Radical
Production in Epithelial Cells. 2005.
9. Grant William
B. A Review of the Evidence
Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017. Sunlight,
Nutrition, and Health Research Center, San Francisco, CA, U.S.A. Correspondence to: William
B. Grant, Sunlight, Nutrition and Health Research Center, PO Box 641603, San
Francisco, CA 94164-1603, U.S.A. Tel: +1 4154091980, e-mail: wbgrant@infionline.net.
11. Grimes, DS, Sunlight, cholesterol
and coronary heart disease D.S. GRIMES, E. HINDLE and T. DYER1 From the
Departments of Medicine and ^Biochemistry, Blackburn Royal Infirmary &
Queens Park Hospital, Blackburn, UK. Q. J. Med. (1996) 89:579-589.
12.
Gurpide, E., K. D. Roberts, M. T. Welch, L. Bandy, and
S. Lieberman. 1966. Studies on the metabolism of blood-borne cholesterol
sulfate. Biochemistry. 5: 3352–3362
13.
Hanvan der Rhee, Jan
WillemCoebergh, Estherde Vries. Is prevention of cancer by sun exposure more than just the
effect of vitamin D? A systematic review of epidemiological studies. 2012
14.
Iwamori, M., Y.
Iwamori, and N. Ito. 1999. Regulation of the activities of thrombin and plasmin
by cholesterol sulfate as a physiological inhibitor in human plasma. J.
Biol. Chem. 125: 594–601.
15.
JIN Li-qin. The
mechanism of anthocyanin inducing nitric oxide production in mice macrophage. JIN
Li-qin1,CHEN Xiu-fang1,LU Jian-xin2,LIU Ming-da3,CHEN Bo-kun2,QIAN
Song4(1.Department of Biochemistry of School of Basic Medical
Ssciences,2.School of Life Sciences, 3.Section 8,the No.1 Affiliated People′s
Hospital,4.School of Pharmacy,Wenzhou Medical College,China). 2011.
16.
Jetten Am,
George MA, Pettit GR et al. Action of phorbol esters, bryostatins, and retinoic
acid on cholesterol sulfate synthesis
relation to the multistep process of differentiation in human epidermal
keratinocytes. Journal Invest
Dermatology 1989, 108-15.
17.
Kazuyuki Kasahara, Takeshi Tanoue, Tomoya
Yamashita,Keiko Yodoi,
Takuya Matsumoto,
Takuo Emoto, Taiji Mizoguchi, Tomohiro Hayashi, Naoki Kitano, Naoto Sasaki1,
Koji Atarashi, Kenya Honda, Ken-ichi Hirata. Commensal Bacteria at the Crossroad between Cholesterol Homeostasis and
Chronic Inflammation in Atherosclerosis. Division of Cardiovascular Medicine,
Department of Internal Medicine, Kobe University Graduate School of Medicine,
Kobe, Japan
18.
Kitchens Richard L.,
Patricia A. Thompson, Robert S. Munford, and Grant E. O’Keefe.2003. Acute
inflammation and infection maintain circulating phospholipid levels and enhance
lipopolysaccharide binding to plasma lipoproteins
19.
Katritsis DG, Ioannidis JP. Percutaneous
coronary intervention versus conservative therapy in nonacute coronary artery
disease: a meta-analysis. Circulation. 2005;111:2906–2912.
20.
Ma Yongjie, Leyuan Xu, Daniel Rodriguez-Agudo,
Xiaobo Li, Douglas M. Heuman, Phillip B. Hylemon, William M. Pandak and Shunlin
Ren, "25-Hydroxycholesterol-3-sulfate regulates macrophage lipid
metabolism via the LXR/SREBP-1 signaling pathway," Am J Physiol
Endocrinol Metab (2008) 295:1369-1379; doi:10.1152/ajpendo.90555.2008
21.
Menon G.K. K.R Feingold. Cholesterol in the
epidermis. Lipids in Skin and Health. Springer Science. 2015. New York. USA.
22.
Langlais, J., M. Zollinger, L. Plante, A. Chapdelaine,
G. Bleau, and K. D. Roberts. 1981. Localization of cholesteryl sulfate in human
spermatozoa in support of a hypothesis for the mechanism of capacitation. Proc.
Natl. Acad. Sci. USA. 78: 7266–7270.
23.
Lemaitre RN Cell membrane trans-fatty
acids and the risk of primary cardiac arrest. Lemaitre RN1, King IB, Raghunathan TE, Pearce RM, Weinmann S, Knopp RH, Copass MK, Cobb LA, Siscovick DS. 2005.
24. Nathan Bryan 2010. The Nitric Oxide (NO) Solution: How to
Boost the Body's Miracle Molecule. Dr. Nathan Bryan, Janet Zand,
Bill Gottlieb.
From keratinocyte to
cancer: the pathogenesis and modelling of cutaneous squamous cell carcinoma. 2012. Journal of Clinical
investigation.
26. Rothberg, Michael B., MD, MPH. Coronary Artery Disease as Clogged Pipes A
Misconceptual Model. Copyright © 2013 American Heart Association
27.
Rodriguez W. V. J. J. Wheeler, S. K. I.imuk,
C. N. Kitson, and M. J. Hope, "Transbilayer Movement and Net Flux of
Cholesterol and Cholesterol Sulfate between Liposomal Membranes",
Biochemistry (1995) 34, 6208-6217.
28.
Sánchez G1,
Nova J,
Rodriguez-Hernandez
AE, Medina RD,
Solorzano-Restrepo
C, Gonzalez J,
Olmos M,
Godfrey K,
Arevalo-Rodriguez
I. Sun protection for preventing basal cell and squamous cell
skin cancers. Cochrane Database Syst Rev. 2016 Jul 25;7:CD011161.
29.
Samsel, Anthony Stephanie Seneff. Review Glyphosate’s
Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut
Microbiome: Pathways to Modern Diseases. 2013. entropy ISSN 1099-4300
www.mdpi.com/journal/entropy
30.
Seneff. Stephanie- Could Sulfur
Deficiency be a Contributing Factor in Obesity, Heart Disease, Alzheimer's and
Chronic Fatigue Syndrome? 2010.
31.
Strott. Charles A. and Yuko Higashi.
Cholesterol sulfate in human physiology:
what’s it all about? Section on Steroid Regulation, Endocrinology and
Reproduction Research Branch, National Institute of Child Health and Human
Development, National Institutes of Health, Bethesda, MD 20892-4510. 2003.
Journal of Lipid Research.
32.
Van Wick
Roeland. Light in Shaping Life
2016.
33. Weller Richard B. Martin Feelisch, Victoria Kolb-Bachofen, Donald Liu, Jon
O. Lundberg, Lucia P. Revelo, Christoph
V. Suschek, . Is sunlight good for our heart? 2010
35.
Yilmaz, Omer H. and
Salvador Alonso. Nutritional Regulation of Intestinal Stem Cells. Department of
Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114,
USA;2018.
36.
Zerkle Aubrey
James Farquhar, David T. Johnston, Raymond P. Cox, and Donald E.
Canfield, "Fractionation of multiple sulphur isotopes during phototrophic
oxidation of sulfide and elemental sulfur by a green sulfur bacterium," Geochimica
et Cosmochimica Acta (2009) Volume 73, Issue 2, 15 January 2009, Pages
291-306; doi:10.1016/j.gca.2008.10.027.
37.
Matteucci C1, Balestrieri E2, Argaw-Denboba A3, Sinibaldi-Vallebona P4. Human endogenous
retroviruses role in cancer cell stemness. 2018
Elsevier Ltd
38.
Expression
of human endogenous retrovirus k envelope transcripts in human breast cancer. Wang-Johanning F1, Frost AR, Johanning GL, Khazaeli MB, LoBuglio AF, Shaw DR, Strong TV.
39.
Vatakencherry
RMJ, Saraswathy L. Association between vitamin D and hypertension in people
coming for health check up to a tertiary care centre in South India.
J Family Med Prim Care. 2019 June
J Family Med Prim Care. 2019 June
40.
Kiani K1, Roohafza H2, Gharipour M3, Dianatkhah, Talaei , Oveisgharan, Sarrafzadegan , Sadeghi M8. The association between the serum
25-hydroxyvitamin D level and cardiovascular events in individuals with and
without metabolic syndrome. ARYA Atheroscler. 2018 Nov.
41.
Senneff,
Stpehanie. Why Statins Do More Harm Than Good by Stephanie Seneff Senior
Research Scientist at MIT (Massachusetts Institute of Technology) September
2011. Senior Research Scientist at MIT's Computer Science and Artificial
Intelligence Laboratory
43.
Dimitrios Papandreou * and Zujaja-Tul-Noor Hamid. The Role
of Vitamin D in Diabetes and Cardiovascular Disease: An Updated Review of the
Literature. Dis Markers. 2015
44.
Rachel D. Zamoiski, Elizabeth K. Cahoon, D. Michal Freedman, and Martha S. Linet. Self-reported sunscreen use and
urinary benzophenone-3 concentrations in the United States: NHANES 2003-2006
and 2009-2012. Environ Res. 2015 Oct; 1
45.
No hay comentarios:
Publicar un comentario